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Krishnakumar Menon

Krishnakumar Menon Amrita Inst itute of Medical Sciences

Positions till present
2007-2008 Senior Research Fellow, Monash Immunology and Stem Cell Laboratory, Monash University, Australia.
2005-2007 Assistant Research Scientist, Department of Neurology, University of Iowa, U.S.A.
2002-2005 Research Investigator, Dept of Pharmacology, University of Iowa, IA, U.S.A.
2000-2002 Postdoctoral research fellow, Dept of Neuroscience, UConn Health Center, U.S.A.
1999-2000 CREST-JST Research Fellow, National Institute for Physiological Sciences, Japan.
1997-1999 JSPS post doctoral fellow at the Neural information laboratory, National Institute for physiological Sciences, Japan.

Awards and honors
Fellowship
Japanese Society for Promotion of Science (JSPS) post doctoral fellowship for two years.

Scholarship
National Multiple Sclerosis Society of Australia (NMSSA) postgraduate research scholarship equivalent to a commonwealth post graduate research grant.

Presentation Grant
International Society for Neurochemistry (ISN) grant to present research at the ISN meeting held in Berlin 1999.

Patents
The Art, Method, Manner, Procees Of Use Of Differential Cerebrospinal Fluid Reactivity To Prefoldin-5 Alpha As A Prognostic Marker For B Cell Acute Lymphoblastic-Leukemia Of Central Nervous System. US patent Application number PCT/IB2014/058167

Projects Grants Awarded

  • ICMR: “Identification of novel molecules of pathogenic significance in central nervous system leukemia" 37 Lakhs. (2010-2013) ≈ $ 67,000. PI: Dr Krishnakumar Menon.
  • Department of Science and Technology: Thematic Unit of Excellence grant to Dr Shantikumar Nair: Dr. Dr Krishnakumar Menon is PI on antibody engineering part of the project. 16Cr (2011-2016) ≈ $ 2.9 million.
  • Department of Biotechnology: Identification of new autoantigens in Rheumatoid Arthritis using an unbiased clinical proteomics approach. 58 lakh. (2012-2015) ≈ $105,000 PI’s: Dr. Krishnakumar Menon and Dr Padmanabha Shenoy.
  • ICMR: Proteomic identification of cerebrospinalfluid reactive mitochondrial proteins in multiple sclerosis. 49 Lakh (2012-2015) ≈ $ 89,000
  • Department of Biotechnology: Structural Bioinformatics Analysis of Glia Maturation factor beta (GMF- β) Target to Exploit its Immunomodulatory role for the Treatment of Multiple Sclerosis Disease. PI’s Dr Gopi Mohan and Dr Krishnakumar Menon. 67 Lakh. (2013-2016).
  • Australia-India Strategic Funds: Nanoengineered autoantigens to prevent and treat autoimmunity. PI’s Dr Krishnakumar Menon and Dr. Manzoor Koyakutty. 72 Lakh (India) and AUD 291960 (Australia). 2013-2016.

Selected Publications out of 30
  • Nair MS, Mony U, Menon D, Koyakutty M, Sidharthan N, Pavithran K, Nair SV, Menon KN. (2015)
    Development and molecular characterization of polymeric micro-nanofibrous scaffold of a defined 3-D niche for in vitro chemosensitivity analysis against acute myeloid leukemia cells. Int J Nanomedicine. 2015 May 15;10:3603-22. doi: 10.2147/IJN.S80397. eCollection.
  • Neuroproteomics: Are we biased in our representation of molecular targets associated with specific domains? Implications in biomarker discovery.Krishnakumar N Menon, Adhwyth Haridasan, Tessy Xavier, Rameshwari Kundargi and Sreepriya Nair (2013). Current Proteomics, 10:1, p 56-66.
  • Krishnakumar N. Menon, David L. Steer, Martin Short, Steven Petratos, Ian Smith and Claude C.A. Bernard. (2011). A novel unbiased proteomic approach to detect the reactivity of cerebrospinal fluid in neurological diseases. Molecular and Cellular Proteomics (doi.10.1074/mcp.M110.000042)
  • Sreepriya Nair, Tessy Xavier, Sharmistha Saha, Satheesh Kumar M.K and Krishnakumar N. Menon (2011). Exploitation of detergent thermodynamics in the direct solubilization of myelin membrane proteins for two-dimensional gel electrophoresis for proteomic analysis. Electrophoresis 32(24):3621-9. doi: 10.1002/elps.201100248.
  • Xavier T., Sreepriya, Ganesan TS, Menon KN. (2010). A simple and efficient method for processing of cell lysates for two-dimensional gel electrophoresis. Electrophoresis. 31:2429-2435.
  • Krishnakumar Menon, Yanghong Wu, Joel Haas, Shailendra K. Sahu, Baoli Yang, and Asgar Zaheer (2007). Diminished degradation of myelin basic protein by anti-sulfatide antibody and interferon-gamma in myelin from glia maturation factor-deficient mice. Neurosci Res. 58:156-163.
  • Krishnakumar Menon, Takeshi Ikeda, Ichiro Fujimoto, Hisashi Narimatsu, Shin-ichi Nakakita, Sumihiro Hase and Kazuhiro Ikenaka. (2005). Changes in N-linked sugar chain patterns induced by moderate to high expression of the galactosyl transferase I gene in a brain derived Cell line, CG4. J. Neurosci. Res. 80: 29-36.
  • Krishna Menon, Matthew N. Rasband, Christopher M Taylor, Peter Brophy, Rashmi Bansal, and Steve E. Pfeiffer. (2003). The myelin-axolemmal complex: biochemical dissection and the role of galactosphingolipids. J. Neurochem. 87: 995-1009.
  • Krishnakumar Menon, Yanghong Wu, Joel Haas, Shailendra K. Sahu, Baoli Yang, and Asgar Zaheer (2007). Diminished degradation of myelin basic protein by anti-sulfatide antibody and interferon-gamma in myelin from glia maturation factor-deficient mice. Neurosci Res. 58:156-163.
  • Krishnakumar Menon, Sara J. Piddlesden and Claude C.A. Bernard. (1997). Demyelinating antibodies to myelin oligodendrocyte glycoprotein and Galactocerebroside induce degradation of myelin basic protein in isolated human myelin. J. Neurochem. 69, 214-222.
  • Terrance G. Johns, Nicole Kerlero de Rosbo, K. K. Menon, Samia Abo, M.Gonzales and Claude C.A. Bernard (1995). Myelin Oligodendrocyte Glycoprotein induces a demyelinating encephalomyelitis resembling multiple sclerosis J. Immunol. 154: 5536-5541.

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