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Laurence  Dubrez

Laurence Dubrez Uni. of Dijon, France

Current position:
Full-time researcher (“Chargée de Recherche de 1ère classe”) in Inserm UMR866
Starting date: January 2004.
Group leader: “IAP team”.

Education:
PhD (1993-1996): University of Burgundy (Dijon, France) – Team Onco-hematology and pharmacology - Cancer Biology and Therapy Department, Inserm CJF 94-04 - Dijon, France - Director: Pr. Eric Solary

Post-doctoral positions:

  • 1997-1998: Molecular and Cellular pharmacology department - School of Biological Sciences - Manchester, GB - Director: Pr. John Hickman
  • 1998-2000: Bases moléculaires de l'initiation et de la progression des cancers du poumon - INSERM E9924 - Institut Albert Bonniot – Grenoble, France – Group leader: Pr. Marie Favrot
  • 2001-2004: Cell Death and Cancer, INSERM U517 – Dijon, France - Director: Pr. Eric Solary

Honors and awards (Selected)
  • 2010 Winner of the first prize Biochemical Journal – ECDO meeting “18th Euroconference on Apoptosis.
  • 2003 Laureate - concour Inserm Chargé de Recherche first class
  • 2001 Post-doctoral Grant from the “ Fondation pour la Recherche Médicale”
  • 1998-200 Post-doctoral Grant from the “Fondation ARC pour la Recherche sur le Cancer”
  • 1997 Post-doctoral Fellowship from the “Ligue contre le cancer”
  • 1995-1996 Doctoral Fellowship from the “Ligue contre le cancer”

Selected Publications:
  • Dubrez L, Rajalingam K. IAPs and cell migration. Semin Cell Dev Biol. 2015 Mar 10. pii: S1084-9521(15)00042-7.
  • Marivin A*, Berthelet J*, Cartier J, Paul C, Gemble S, Morizot A, Boireau W, Saleh M, Bertoglio J, Solary E and Dubrez L. cIAP1 regulates TNF-mediated cdc42 activation and filopodia formation. Oncogene 2014 Nov 27; 33(48):5534-45.
  • Dubrez L, Berthelet J, Glorian V. IAP proteins as targets for drug development in oncology. OncoTargets and Therapy 2013, Sept 16, 6, 1285 – 1304.
  • Cartier J*, Berthelet J*, Marivin A, Gemble S, Edmond V, Plenchette S, Lagrange B, Hammann A, Dupoux A, Delva L, Eymin B, Solary E, Dubrez L. Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription. J Biol Chem. 2011 Jul 29;286(30):26406-17.
  • Dupoux A., Cartier J., Cathelin S., Filomenko R, Solary E. and Dubrez-Daloz L. cIAP1-dependent TRAF2 degradation regulates the differentiation of monocytes into macrophages and their response to CD40-ligand. Blood. 2009 Jan 1;113(1):175-85.
  • Didelot C, Lanneau D, Brunet M, Bouchot A, Cartier J, Jacquel A, Ducoroy P, Cathelin S, Decologne N, Chiosis G, Dubrez-Daloz L, Solary E, Garrido C. Interaction of heat-shock protein 90beta isoform (HSP90beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation. Cell Death Differ. 2008 May;15(5):859-66.
  • Dubrez-Daloz L., Dupoux A, Cartier J. IAPs: more than just inhibitors of apoptosis proteins. Cell cycle, 2008 Apr;7(8):1036-46.
  • Plenchette S, Cathelin S, Rebe C, Launay S, Ladoire S, Sordet O, Ponnelle T, Debili N, Phan TH, Padua RA, Dubrez-Daloz L*, Solary E*. Translocation of the inhibitor of apoptosis protein c-IAP1 from the nucleus to the Golgi in hematopoietic cells undergoing differentiation: a nuclear export signal mediated event. Blood. 2004 Oct 1;104(7):2035-43
  • Hurbin A*, Dubrez L*, Coll JL, Favrot MC. Inhibition of apoptosis by amphiregulin via an insulin-like growth factor-1 receptor-dependent pathway in non-small cell lung cancer cell lines. J Biol Chem. 2002 Dec 20;277(51):49127-33. (*equal contribution)
  • Sordet O*, Rebe C*, Plenchette S, Zermati Y, Hermine O, Vainchenker W, Garrido C, Solary E, Dubrez-Daloz L. Specific involvement of caspases in the differentiation of monocytes into macrophages. Blood. 2002 Dec 15;100(13):4446-53. (*equal contributions)
  • Dubrez L, Coll JL, Hurbin A, de Fraipont F, Lantejoul S, Favrot MC. Cell cycle arrest is sufficient for p53-mediated tumor regression. Gene Ther. 2001 Nov;8(22):1705-12.
  • Dubrez L, Coll JL, Hurbin A, Solary E, Favrot MC. Caffeine sensitizes human H358 cell line to p53-mediated apoptosis by inducing mitochondrial translocation and conformational change of BAX protein. J Biol Chem. 2001 Oct 19;276(42):38980-7.
  • Griffiths GJ*, Dubrez L*, Morgan CP, Jones NA, Whitehouse J, Corfe BM, Dive C, Hickman JA. Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis. J Cell Biol. 1999 Mar 8;144(5):903-14. (* equal contributions)
  • Dubrez L, Eymin B, Sordet O, Droin N, Turhan AG, Solary E. BCR-ABL delays apoptosis upstream of procaspase-3 activation. Blood. 1998 Apr 1;91(7):2415-22.
  • Dubrez L, Savoy I, Hamman A, Solary E. Pivotal role of a DEVD-sensitive step in etoposide-induced and Fas-mediated apoptotic pathways. EMBO J. 1996 Oct 15;15(20):5504-12.
  • Dubrez L, Goldwasser F, Genne P, Pommier Y, Solary E. The role of cell cycle regulation and apoptosis triggering in determining the sensitivity of leukemic cells to topoisomerase I and II inhibitors. Leukemia. 1995 Jun;9(6):1013-24.

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