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S. Mahalingam

S. Mahalingam Indian Institute of Technology – Madras

Professional Experience
May 2010- Professor, Dept. of Biotechnology, Indian Institute of Technology Madras, Chennai.
May 2007 – May 2010 Associate Professor, Dept. of Biotechnology, Indian Institute of Technology Madras, Chennai.
May 2005 –May 2007 Staff Scientist-V, Centre DNA Fingerprinting and Diagnostics, Hyderabad.
Aug-Dec. 2003 Visiting Scientist, Institute of Molecular and Cellular Biology, Singapore
March-May 2002 Visiting Scientist, University of Pittsburgh, Pittsburgh, USA
Jan 2001-April 2005 Staff Scientist-IV, Centre DNA Fingerprinting and Diagnostics, Hyderabad.

Current Research Interest
1. Tumor biology
a. understanding the cross talk between tumor suppressors [p53 and RASSF family proteins] and activators of cell proliferation [Nucleolar GTPase]), mechanism of Ras associated tumor suppressor (RASSF super family) mediated cell growth control.

b. Nucleolus on cell proliferation and cancer
nucleolus play a very important role in rRNA production, processing, and ribosome biogenesis. Understanding the role nucleolar proteins in cell proliferation and tumor development is critical.

2. Regulation of nucleo-cytoplasmic transport proteins
Identification and characterization of protein nuclear and nucleolar transport using both cellular and viral proteins.

3. Molecular pathogenesis of HIV/AIDS
a. Virus-host interaction, mechanism of HIV mediated cell cycle arrest, and role of integrase during very early steps in viral infection.
b. Since there is no animal model system available to study the AIDS pathogenesis and the currently available small animal models systems are not completely representing the natural viral host, we are involved in developing simple viral model system (surrogate virus model) using HIV envelope genes to understand the HIV pathogenesis.
c. Developing a broadly neutralizing antibodies against envelope protein to block HIV replication.

Publications
Peer-reviewed International Journals (Selected) (total of 48)

1. Datta. D, Anbarasu K, Suryaraja R, Sneha Priya. R, Desai. P and Mahalingam. S. (2015). Nucleolar GTP binding protein-1 (NGP-1) promotes G1 to S phase transition by activating cyclin dependent kinase inhibitor p21Cip1/Waf1 J. Biol. Chem. 290(35):21536-52

2. Sneha Priya R, Veena M, Kalisz I, Whitney S, Priyanka D, LaBranche CC, Sri Teja M, Montefiori DC, Pal R, Mahalingam S (2015). Antigenicity and immunogenicity of a trimeric envelope protein from an Indian clade C HIV-1 isolate. J. Biol. Chem. 290 (14):9195-208.

3. Thoompumkal IJ, Subba Rao MR, Kumaraswamy A, Krishnan R, Mahalingam S (2015) GNL3L Is a Nucleo-Cytoplasmic Shuttling Protein: Role in Cell Cycle Regulation. PLoS One. 10(8):e0135845. doi: 10.1371.

4. Menon V, Sneha Priya R, Labranche C, Montefiori D, Mahalingam S, Kalyanaraman VS, Pal R (2015) Characterization of protective immune response elicited by a trimeric envelope protein from an Indian clade C HIV-1 isolate in rhesus macaques. J Med Primatol. doi: 10.1111/jmp.12178.

5. Suryaraja R, Anitha M, Anbarasu K, Kumari G, Mahalingam S. (2013). The E3 ubiquitin ligase Itch regulates tumor suppressor protein RASSF5/NORE1 stability in an acetylation-dependent manner. Cell Death Dis. 4:e565-574.

6. Boddapati N, Anbarasu K, Suryaraja R, Tendulkar AV, Mahalingam S. (2012). Subcellular distribution of the human putative nucleolar GTPase GNL1 is regulated by a novel arginine/lysine-rich domain and a GTP binding domain in a cell cycle-dependent manner. Journal of Molecular Biology 416(3):346-66.

7. Pankaj Gupta, P. K. Singhal, P. Rajendrakumar, Y. Padwad, A. V. Tendulkar, V.S. Kalyanaraman, R. E. Schmidt, A. Srinivasan, and Mahalingam S. (2011). Mechanism of host cell MAPK/ERK-2 Incorporation into Lentivirus Particles: Characterization of the Interaction between MAPK/ERK-2 and Proline-rich Domain Containing Capsid Region of Structural Protein Gag. Journal of Molecular Biology 410(4):681-697.

8. Kumari G, Singhal PK, Suryaraja R, Mahalingam S (2010) Functional Interaction of the Ras Effector RASSF5 with the Tyrosine Kinase Lck: Critical Role in Nucleocytoplasmic Transport and Cell Cycle Regulation. Journal of Molecular Biology 397(1):89-109.

9. Kumari G and Mahalingam S. (2009). Extracellular signal-regulated kinase 2 (ERK-2) mediated phosphorylation regulates nucleo-cytoplasmic shuttling and cell growth control of Ras-associated tumor suppressor protein, RASSF2. Exp Cell Res. 315(16):2775-2790.

10. Gita Kumari, P. K. Singhal, M.R.K., Subba Rao, and S. Mahalingam. (2007). Nuclear Transport of Ras Associated Tumor Suppressor Proteins: Different Receptor Binding Specificities for Arginine-rich Nuclear Targeting Signals. Journal of Molecular Biology. 367: 1294-1311.

11. Subba Rao, M.R.K., Gita Kumari., D. Balasundaram., R. Sankaranarayanan and S. Mahalingam. (2006). A Novel Lysine-rich domain and GTP Binding Motifs Regulates the Nucleolar Retention of Human Guanine Nucleotide Binding Protein, GNL3L. Journal of Molecular Biology. 364: 637-654.

12. Singhal,P. K., P. Rajendra Kumar., M. R. K. Subba Rao and S. Mahalingam (2006). Nuclear Export of Simian Immunodeficiency Virus Vpx Protein. Journal of Virology. 80: 12271-12282.

13. Singhal, PK., Rajendra Kumar. P., Subba Rao. M.R.K., Kyasani. M., and Mahalingam. S. (2006). Simian Immunodeficiency Virus Vpx is imported into the nucleus via importin alpha dependent and independent pathways. Journal of Virology. 80: 526-536.

Book Chapters
1 Rajendra Kumar. P., Singhal, P. K, and Mahalingam. S. (2004) A transferable signal mediates nuclear import of simian immunodeficiency virus Vpx protein. 173-178. Deep Roots, Open Skies: New Biology in India. Eds. S.K. Basu., Batra J.K and D.M. Salunke. Narosa Publishing House, New Delhi, India

2 Srilakshimi. P., Rajendra Kumar. P, and Mahalingam. S. (2007) HIV-1 Pathogenesis: Role of viral protein R. 186-200. Research Issues in HIV/AIDS. Eds. D. Raghunath and C. Durga Rao. Tata McGraw-Hill Publishing Company Ltd. New Delhi, India.

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